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Consistently, RNAi knockdown of TH significantly alleviates the rotenone- and mutant -syn-induced degeneration of dopaminergic neurons in a Drosophila PD model [35]

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This mechanistic hypothesis is supported by clinical data from the SURMOUNT-5 trial, which showed that GI adverse events led to treatment discontinuation less frequently with tirzepatidea dual GIP/GLP-1than with semaglutide, a selective GLP-1RA