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This study was supported by the National Natural Science Foundation of China (No 81403484)
Mooney CT, Thoday KL
In addition to inhibiting the expression of COX-2 in lung cancer cells, IGFBP-4 also inhibited the proliferation, migration and metastasis of cancer cells through the modulation of the PI3K/AKT, ERK and CREB pathways, which highlights the anticancer value of IGFBP-4 (111)
Patients with advanced prostate cancer are often treated with endocrine therapy including maximal androgen blockade (anti-androgens combined with castration) and classical androgen deprivation (orchiectomy or luteinizing hormone-releasing hormone agonists) [5]
[1] Additionally, GLP-1 receptor agonists slow gastric emptying and promote satiety through central nervous system pathways, contributing to weight reduction in many patients
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