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Once-daily oral administration of ID110521156 in diabetic monkeys resulted in reduced plasma glucose levels, increased insulin secretion, decreased food intake, and weight loss

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In vitro studies have shown that exendin-4 enhances lipolysis and fatty acid oxidation by upregulating SIRT1 expression and activity in differentiated 3T3-L1 adipocytes

Conversely, zinc deficiency or chelation of tissue zinc improves anti-tumor immunity and enhances responses to immunotherapies such as PD-1, particularly in melanoma models [328]

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