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To be eligible patients must have: A Body Mass Index (BMI) of 40 or more AND Have been diagnosed with AT LEAST FOUR of the following: High blood pressure High cholesterol or abnormal blood fats Sleep apnoea Heart disease Type 2 diabetes For more details on who will become eligible over the coming years, see page 7 of the official NHS Guidance
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MI exerts indirect anti-inflammatory actions by normalizing insulin and lipid metabolism, reducing activation of the NLRP3 inflammasome, and decreasing systemic cytokine output (Ref)
Hypoxia-inducible factor 1alpha (HIF-1alpha)-mediated hypoxia increases BACE1 expression and beta-amyloid generation
