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Long-Term Considerations After an Overdose Event A single accidental excess dose of AOD-9604 is unlikely to cause lasting harm based on available evidence

Furthermore, no mutagenic or genotoxic effects have been reported in standard tests

[48] Drugs that modify cytochrome P-450 enzyme are referred to as either inhibitors or inducers

Promising results from a study showed 12- to 13-times higher bioavailability using solid lipid nanoparticles compared to standard oral apomorphine

Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions