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The high failure rates of experimental drugs in late-stage clinical trials highlight a disconnect between preclinical findings and human studies, largely due to inadequate disease models that fail to capture the full complexity of human AD pathology ( in vitro and in vivo studies showing their efficacy in reducing oxidative stress, neuroinflammation, and A accumulation (Mohamed Yusof and Mohd Fauzi 2024)

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PMID: 29756566 View source Malinda KM, et al

10.2174/0929867329666220801165849 50 MillsG

Metabolomic changes begin to reveal the some of the underlying causes of vulnerability in the motor cortex