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doi:10.2174/1875044301205010047 [25] Ueno PM, Ori RB, Maier EA, et al

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Common reported effects in clinical use include mild injection site reactions with subcutaneous administration, occasional digestive changes when taken orally, and rare reports of fatigue or dizziness

Rather than manipulating individual pathways in isolation, effective intervention will likely require coordinated, context-dependent modulation of chaperones, autophagy, UPS activity, and ER stress responses