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Elevated GGT expression can indicate the early-stage risk of tumor development, as suggested by an epidemiological study linking high GGT expression with increased risk of prostate cancer development (145)

In animal cells the fate of ITCs is well characterized: conjugation to glutathione by GSTs resulting in its intracellular depletion and subsequent degradation of dithiocarbamates through enzymatic events catalysed by -glutamyltranspeptidase, cysteinylglycinase and N -acetyltransferase via the mercapturic acid pathway 76

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Chen Q, Chen O, Martins IM, et al