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In a 48-week phase 2 study of retatrutide involving 338 overweight or obese non-diabetic participants, researchers observed dose-dependent decreases in weight and improvements in waist circumference, blood pressure, levels of glycated hemoglobin, fasting glucose and insulin, and most lipid metrics
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[78] found that Lira inhibited proprotein convertase subtilisin/kexin type 9 (PCSK9) expression in HepG2 cells and db/db mice through hepatocyte nuclear factor 1 (HNF1)-dependent mechanism, and may inhibit LDLR expression in db/db mice through PCSK9 independent pathway, and ultimately reduce liver cholesterol accumulation
Additional research has also demonstrated that professional carnitine administration can be used to lower clinically high blood pressure levels, treat congestive heart failure, manage cardiac ischemia (the restriction of blood flow to the heart), and peripheral arterial diseases, a condition characterized primarily by poor circulation in the legs (known as intermittent claudication)
Studies also found both drugs to be effective at preventing certain heart problems in adults with type 2 diabetes and heart disease
