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Weight regulation : In mouse studies, systemic administration produced a progressive reduction in body weight and up to a ~35% decrease in white adipose tissue mass

One Mayo Clinic forum discussion acknowledged that an alternating 6-month approach is "creative" and might allow you to get benefits from both while minimizing cumulative side effects

Stratification of the data revealed that cognitive benefits were seen only in those without dementia at baseline and in trials of more than one year in duration (68)

Longevity and cellular health research explores fundamental processes that determine cellular and organismal lifespan

Of those, 45 different categories of gastrointestinal issues were reported, including pancreatitis, constipation, nausea, vomiting, and diarrhea