Weight loss peptides (GLP-1 agonists) Examples : Semaglutide, Tirzepatide, Liraglutide Common side effects (mostly GI-related): Nausea : Frequency: 40-50% of users initially Severity: Mild to moderate Duration: Usually 1-3 weeks (improves with continued use) Management: Start low dose, increase gradually, eat smaller meals Constipation : Frequency: 20-30% of users Severity: Mild to moderate Management: Increase fiber, water, consider stool softener Diarrhea : Frequency: 15-20% of users Severity: Mild Duration: Usually temporary Management: Probiotics, reduce fatty foods Fatigue : Frequency: 20-30% initially Severity: Mild to moderate Duration: 2-4 weeks (improves as caloric deficit stabilizes) Management: Adequate protein, electrolytes, patience Reduced appetite (intended effect): Not a side effect - this is the mechanism Goal: 15-20% reduction in caloric intake Result: Weight loss Read our semaglutide vs tirzepatide comparison

The provider will review your medical history, BMI, and any relevant health conditions before prescribing
The MHRA told us that anything claiming to be retatrutide is illegal and unsafe, and that legitimate weight loss medicines are only available on prescription
But the dose-response data strongly suggests that peak concentration, not just total exposure, matters for glucagon receptor activation
Semaglutide is approved for the treatment of obesity in a subcutaneous formulation at a dose of 2.4 mg OW