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However, MAHT at a dosage of 8 mg deeply decreased Ig E level (61 %) and HLA-DR expression (57 %) in a significantly manner

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The duloxetine treatment recommendation for CIPN is based on the results from a randomized controlled trial in 231 patients taking oxaliplatin or taxanes, which found that those receiving duloxetine (30 mg/day for one week followed by 60 mg/day for an additional four weeks) reported greater reduction in pain than those in the placebo group (Smith 2013)

They used moderate concentrations rather than jumping to the highest available