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Nrf2 is an important transcription factor involved in iron metabolism and oxidative stress in the brain

A 24-week clinical trial published in Obesity Research (2011) tested AOD-9604 against placebo for fat reduction and found no statistically significant difference between groups a result that has kept the compound classified primarily as a research-stage peptide rather than one with an established, reproducible metabolic effect

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At the 4 mg dose level in the phase 2 trial, participants averaged approximately 3-5% body weight reduction by week four to six