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In contrast, exosomes released by oligodendrocytes, Schwann cells, astrocytes, microglia, mesenchymal stromal stem cells, epithelial cells, and embryonic CSF sources can maintain the normal functions of neurons and neural stem cells [263]

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Liposomes mimic the lipid structure of the skin barrier, enabling copper peptides to cross the stratum corneum more effectively and reach deeper epidermal and dermal layers

On the other hand, in cholestatic individuals in whom the NGS panels have not found pathogenic mutations, a comprehensive study like WES, performed over the full exome, can find potential gene candidates for a cholestasis association, as was the case with the most recently discovered PFIC, PFIC 13 [37, 90]

Table 1 Diverse sources and types of polyphenols, their antioxidant properties, and modes of action