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This is because your body cant metabolize protein needed to build or maintain muscle mass

Acetyl-CoA regulates lipid metabolism and histone acetylation modification in cancer

(2016) Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia, Oncotarget , 7 , 14659-14672, doi: Njlsson, R., and Norgren, S

In light of these intracellular observations (Kokame et al, 1996), we hypothesize that changes in the intracellular redox state associated with elevated homocysteine levels can alter the expression of multiple genes involved in other specific cellular functions that could be partially responsible for vascular disorders associated with moderate hyperhomocysteinemia

This makes it vital to energy metabolism in all living organisms