Originally investigated for its potential to combat obesity, metabolic syndrome, and age-related decline, this NNMT (nicotinamide N-methyltransferase) inhibitor has shown promise in boosting fat metabolism, preserving lean muscle mass, and increasing energy efficiency
[9] [13] [14] Rarely, people with a seizure disorder may experience more frequent seizures, and severe allergic reactions have been reported
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In mouse models of highfat dietinduced liver steatosis, it significantly inhibits hepatic NNMT activity, reduces NAM methylation, increases NAD+ and SAM levels, enhances mitochondrial fatty acid oxidation, reduces hepatic triglyceride and lipid accumulation, lowers lipotoxicity markers (e.g., malondialdehyde, transaminases), improves hepatocellular injury, and reverses steatosis
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