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Stages of life, lifestyle changes, diet and health conditions all impact the amount of vitamin B12 you need to avoid a deficiency

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One of the most common other nutrients to consider when supplementing the methylation cycle is the proper form of B12

[2] A deficiency of thyroid hormones can reduce basal metabolic rate up to 50%, while an excessive production of thyroid hormones can increase the basal metabolic rate by 100%