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For example, MC4R knockout mice exhibit significantly increased hypothalamic expression of neuropeptide Y (NPY) and agouti-related protein (AgRP), while pro-opiomelanocortin (POMC) expression is decreased compared with wild-type controls [56]

[14] GLP-1 medications at doses licensed for diabetes often produce more modest weight loss of 2-6kg

Metabolomics studies focusing on starvation in echinoderms remain limited, but studies on the crown-of-thorn starfish have documented starvation-induced changes at the gene expression level, linked to glycolysis and the citrate cycle 49 and at the microbiome level, suggesting adaptions in microbial networks during starvation 50 , supporting similar responses of the current investigation, albeit at different levels of biological organization

J., Olpin, S., Andresen, B

This distinction has profound functional consequences for immune cell biology