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Oxidative stress induced by overfeeding can also disrupt insulin signalling [45]
2022 Dec 29;16:4449-4461
Schulman JD, Goodman SI, Mace JW, Patrick AD, Tietze F, Butler EJ: Glutathionuria: inborn error of metabolism due to tissue deficiency of gamma-glutamyl transpeptidase
This special interplay further highlights that the loss of any one system can overwhelm the compensatory capacity of the others, forcing the CNS into a state of redox imbalance, glial activation, and progressive inflammation (Figure 1)
The result is a solution containing broken, ineffective fragments of the original compound
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