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This was supported by a recent metanalysis in which, twenty- two randomized controlled trials involving 61,412 patients who were either T2DM patients with or without cardiovascular disease or patients with cardiovascular disease alone, were included in the meta-analysis, and results have shown the diastolic function according to echocardiography was significantly improved by GLP-1R agonists [88]

Hypothyroidism can be caused by various factors, such as autoimmune disease, iodine deficiency, medication, surgery, or radiation

In the nigrostriatal tract system, dopamine undergoes autooxidation or oxidative deamination by monoamine oxidase-B, both of which aggravates with age, leading to increased production of peroxides and hydroxyl radicals 41

Drewitt PN, Butterworth KR, Springall CD, Walters DG, Raglan EM

Kruppel-like factor 2 is a transcriptional regulator of chronic and acute inflammation