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The table below highlights the variables that most often determine whether a project gives a useful, interpretable product instead of a difficult polar mixture

And, you know, interesting other pathways these days, what I really recommend if you're going to do NAD is also really thinking about the two salvage pathways that NAD can break down into

57 SeiwerthS.RucmanR.TurkovicB.SeverM.KlicekR.RadicB.et al (2018)