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The unexpected paradoxical worsening of psoriatic lesions after treatment with liraglutide was hypothesized to be due to cytokine imbalance with the release of IFN- and leukocyte chemotaxis after liraglutide-induced inhibition of TNF-, IL17, and IL23

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The timing of exposure varied across the studies: two analyzed any exposure during pregnancy, whereas the other five focused on first-trimester exposure