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Metabolic pathways: B12 is a cofactor in two critical reactions: Methylmalonyl-CoA mutase: Converts methylmalonyl CoA (from odd-chain fatty acids and some amino acids) into succinyl-CoA, which enters the Krebs (TCA) cycle to make ATP (cellular energy)

If burning stays within one to two inches of the injection site and fades within 72 hours, it's an expected local reaction that does not require medication discontinuation

Speaking to MNT , Ali emphasized that this effect is minor in comparison to the GLP-1 medications and it is important to modify your diet and lifestyle to experience consistent weight loss results.

Parallel efforts are exploring new indications, including neurodegenerative and substance use disorders, metabolic liver disease, arthritis, type 1 diabetes and inflammatory bowel disease

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