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Although the findings are not always consistent, changes in the brainstem have been very common, especially structural changes, mainly a decrease in grey or white matter volume in patients, often pronounced in relation to the symptom burden of fatigue, pain and autonomic symptoms

Right behind Novo is Roche, which made its own $3.5 billion MASH play by acquiring 89bio and its late-stage asset pegozafermin.

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The lack of sterile procedures in the making of these drugs has resulted in everything from localized infection at injection sites to systemic shock states