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Senolytic FOXO4-DRI can inhibit FOXO4 binding by disrupting the p53-FOXO4 interaction and selectively cause apoptosis via p53 nuclear exclusion in senescent cells and aging mouse models, which may be a promising approach for preventing senescence 11

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Studies show that chemotherapy drugs induce widespread cellular senescence in healthy tissues, with these treatment-induced senescent cells secreting inflammatory factors that cause persistent fatigue, organ dysfunction, and accelerated aging in cancer survivors