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Any discomfort is easily treated with over-the-counter pain medication, allowing patients to jump back into their activities without hesitation

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Venlafaxine extended release in the treatment of painful diabetic neuropathy: a double-blind, placebo-controlled study

At minimum, you'd want IGF-1, a complete metabolic panel, fasting insulin, lipid panel, inflammatory markers (hsCRP, IL-6), a full hormone panel, and a DEXA scan or equivalent body composition assessment

The GLP-1 receptor agonists used in metabolic medicine (semaglutide, tirzepatide) are synthetic versions designed to last longer than your body's own GLP-1