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In research models, elevated NNMT activity has been associated with: lower NAD levels, with downstream effects on mitochondrial energy production
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These include its impact on hormonal signaling pathways like GnRH and prolactin, its role in activating enzymatic processes that affect testosterone synthesis, its modulation of androgen receptor sensitivity, and its protection against oxidative stress and homocysteine toxicity
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4.4.2 Preclinical studies Preclinical studies have further elucidated the potential mechanisms underlying the antidepressant and anxiolytic effects of SF
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