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Extra weight increases mechanical stress on the knee, and "visceral adipose tissue secretes adipocytokines and other soluble mediators that increase pain." Felson added that the trial's findings are similar to those from a 2023 study that examined the effects of GLP-1 receptor agonists on adults who had both type 2 diabetes and knee osteoarthritis

Cortisol and adrenaline lower sensory thresholds, making already-sensitive skin feel even more reactive

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Timeline: onset within 30 minutes to 4 hours, duration of 24 to 72 hours