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Conditions such as pernicious anemia or gastrointestinal disorders can impact the effectiveness of the shots

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Stability evaluation

With that in mind here are the injection sites you can use on your body for B12 shots: Mid-thigh (right into your quadriceps): This is the preferred site if you are self-injecting

Injections, on the other hand, provide high bioavailability and typically result in faster improvement of symptoms Injections may be a better choice if: Youve been diagnosed with a B12 deficiency You follow a vegetarian or vegan diet You take medications that impair absorption You want faster, more noticeable results Ideal B12 Injection Dosage & Frequency Theres no one-size-fits-all dosage for B12 injections