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Marked decreases in glial cell line-derived neurotrophic factor (GDNF) were also observed in TLR2-deficient and microbiota-depleted mice, whereas supplementation with GDNF or TLR2 agonist restored the ENS function, indicating that both are prerequisites for ensuring the integrity of ENS ( 3.3 Neurotoxic effects Clinical studies (Gomes et al., 2017) indicate that serum lipopolysaccharide (LPS) levels in patients with T2DM are 1.66-fold higher than in healthy individuals

This article examines what each compound is, how they work, the current evidence base, and the significant regulatory and safety considerations UK patients and clinicians need to understand