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In rodent satellite-cell models, sustained IGF-1R activation by long-acting analogues increased myotube diameter by 30-40% compared with vehicle, an effect attenuated by the PI3K inhibitor LY294002 [5]

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While this evidence in adults is promising, further research is warranted to specifically evaluate the potential role and efficacy of L-carnitine in modulating inflammation and oxidative stress related to bacterial infections in pediatric populations, particularly where mitochondrial dysfunction may play a key role