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In contrast, binding of nuclear factor of activated T cells 5 to the promotor leads to downregulated Prx2 expression and increased ferroptosis in pancreatic -cells during progression of obese type 2 diabetes mellitus [155]

This, together with the previously reported inactivation of TrxR via modification of the selenocysteine residue in the active site and the fast reaction with GSH, will disrupt the redox balance in the cell and affect processes such as DNA replication and repair and neutralization of ROS

Dietary phloridzin reduces blood glucose levels and reverses Sglt1 expression in the small intestine in Streptozotocin-induced diabetic mice

Bariatric Surgery versus Intensive Medical Therapy for Diabetes - 5-Year Outcomes