Safety, pharmacokinetic, and pharmacodynamic evaluation of a 2-(2-methoxyethyl)-d-ribose antisense oligonucleotide-triantenarry n -acetyl-galactosamine conjugate that targets the human transmembrane protease serine 6
Patients arrive with tendon injuries that have not responded to physical therapy, gut issues that antibiotics made worse, and joint inflammation that has been managed but never resolved
doi: 10.1530/eje-15-0306 4 De LeoSLeeSYBravermanLE
Frago LM, Paeda C, Dickson SL, Hewson AK, Argente J, Chowen JA
Dysbiosis is defined as the loss of beneficial microbes, expansion of pathobiont microbes, or loss of the diversity of the microbes (Petersen and Round, 2014)