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Trulicity over 5 years: Amount of weight lost: 1012 lbs (maximum possible) Cost: $55,000$60,000 (out-of-pocket) or $1,500$6,000 (covered by insurance) Side effects: Continues as long as the drug continues being used Consequence of stopping: Weight gain after 612 months One-time procedure of bariatric surgery: Weight loss: 6080% of excess body weight Cost: $15,000$25,000 self-pay or covered by multiple insurance plans Side effects: Recovery from surgery (average 24 weeks) Long-term effect: Permanent structural change

However, without continued NNMT inhibition, some metabolic advantages will diminish over time

Obtain a Letter of Medical Necessity When traveling via public transportation, overseas, or abroad, some entities may require a letter of medical necessity

In some cases, you can feel the effects immediately if its a hydration or vitamin drip

Shaikh MA, Memon I, Ghori RA