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The approval represented a significant milestone as Wegovy became the first FDA-approved treatment for chronic weight management in adults since 2014, strengthening the adoption of long-acting GLP-1 analogues in obesity care In August 2021, results from the STEP 1 clinical trial of once-weekly semaglutide 2.4 mg were published in the New England Journal of Medicine, showing substantial weight reduction in adults with overweight or obesity without diabetes