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Glutathione (GSH), composed of gamma-glutamylcysteinylglycine, stands as the most abundant intracellular thiol in aerobic cells, and its synthesis by GSS is essential for diverse cellular processes

Oxidative stress: oxidants and antioxidants

Factors like stress, poor diet, environmental toxins, and UV exposure can further deplete these levels, leading to signs of aging such as dull skin, brittle nails, and thinning hair

Yan T, Zhang Z, Li D (2020) NGF receptors and PI3K/AKT pathway involved in glucose fluctuation-induced damage to neurons and -lipoic acid treatment

Unfortunately, there is no clear answer as the duration and intensity are unique to each person