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Figure 2 indicate that, in the selected cohort, HA + GSH-C4 treatment did not produce a statistically significant overall effect on the Schirmer test (Control formulation: 12.35 1.47 vs
16 h underscore the widely acknowledged clinical observation that early intervention is crucial [40,41]
The use of some glucose-lowering drugs, specifically sulphonylureas and insulin, is largely limited by the risk of hypoglycemia, which is minimized when using GLP-1RA and SGLT2i 21
Administration timing aligned with circadian MC1R expression (early morning, 68 AM) extends the anti-inflammatory window from 6 hours to 912 hours based on receptor occupancy data
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