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In some cases, however, a large hurdle remains to preparing the LNPs for the life sciences researchers who are tasked with finding a therapeutic target, since they generally possess neither the equipment required for LNP formulation nor the ability to measure the physicochemical properties

24 This raises a conceptual distinction between active signal transmission, in which a death-inducing signal is directly relayed, and state transmission, in which recipient cells are rendered permissive to subsequent ferroptosis

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