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Injection site reactions typically occur at the site of administration (abdomen, thigh, or upper arm) and have distinct characteristics from acne, making confusion between the two unlikely in most cases
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H., Holbrook, K
Skin mast cells carry MRGPRX2, a receptor that fires on cationic, aromatic ("cationic amphiphilic") molecules and releases histamine redness, swelling, the classic wheal. It is confirmed for SS-31, which activates the receptor well below its injection concentration
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