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Additionally, the neurogenic locus notch homolog protein 1 (NOTCH1) signalling pathway [133] and the phosphoinositide 3-kinase (PI3K)-protein kinase B (AKT) pathway [176, 177], have also been shown to augment NFE2L2 transcription, and consequently activate NRF2 signalling, thus maintaining redox balance
This means bones can break easily, even from small injuries or accidents
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Whether studied individually for selective pathway investigation or together for dual-mechanism research, both compounds offer significant research utility for programmes in endocrine biology, IGF-1 axis research, body composition science and pituitary function investigation
