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Rather, the focus seems to be shifting to a more holistic approach, incorporating a nutrient-dense diet, regular exercise, and, for some, that includes compounded GLP-1 injections or oral weight-loss medications

Contact your GP or diabetes specialist nurse within 24-48 hours if you notice: Persistent rash or hives lasting more than a few days Injection site reactions that worsen rather than improve, or don't resolve within a week Signs of localised infection: increasing redness, warmth, swelling, or pus at injection sites New skin lesions, particularly if they're painful, bleeding, or changing rapidly Unexplained bruising or skin discolouration Any skin changes accompanied by other symptoms such as joint pain, fever, or general malaise Persistent vomiting or diarrhoea, especially in hot weather, which could lead to dehydration Routine discussion at your next scheduled appointment is appropriate for: Mild, stable injection site reactions that are improving Questions about sun protection or general skin care whilst taking Ozempic Cosmetic concerns related to weight loss Gradual improvement in pre-existing diabetes-related skin conditions Your diabetes care team should conduct regular medication reviews, typically every 3-6 months, which provide an opportunity to discuss any skin-related concerns

The field still lacks standardized language and diagnostic criteria for clinical and preclinical obesity, as well as data on the long-term impact of nutritional interventions in patients using GLP-1s, they wrote

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The SURMOUNT-1 trial (tirzepatide, published in NEJM 2022) demonstrated that participants with obesity or overweight without diabetes who received tirzepatide experienced weight reductions of 16.0% (5mg), 21.4% (10mg), and 22.5% (15mg) over 72 weeks