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One meta-analysis that included findings from 22 randomized controlled trials with a total of 3,604 participants found treatment with folic acid not only lowered homocysteine levels but also improved cognitive function in those with mild cognitive impairment

Symptoms are commonly mild to moderate, and many patients report a reduction in severity after the initial escalation phase, although delayed gastric emptying can persist to some degree

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In published case reports, salivary flow recovered within 4-16 weeks with appropriate management