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A Brief History of GH Secretagogues The GH secretagogue story begins in the 1970s when Cyril Bowers discovered that small synthetic peptides based on enkephalin could release GH from pituitary cells without acting through opioid receptors

Concerns about the potential association between certain diabetes medications and cardiovascular disease meant that in 2010 the FDA approved liraglutide on condition that Novo Nordisk conduct a post-marketing study to evaluate the drug's effect on the incidence of major cardiovascular events (Nielsen, DeChiaro, Goldman)

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Side effect profiles may differ from other therapies, and individual responses vary