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Clinical therapy of targeting ferroptosis in human diseases Numerous preclinical studies have demonstrated that iron acts as a potent pro-oxidant, contributing to the development and progression of tumors, central nervous system diseases, metabolic diseases, autoimmune diseases, and cardiovascular diseases through the production of highly reactive and cytotoxic free radicals

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Another study reported that the depletion of VHL, a major tumor suppressor of clear cell renal cell carcinoma (ccRCC), leads to the stabilization of the hypoxia inducible factors HIF-1 and HIF-2

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Fish Oil Source: Prefer fish oil derived from smaller, sustainably caught fish such as sardines and anchovies, whichtypically havelower mercury levels