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[36] This degradation process releases the drug payload specifically into cancerous or tumorous tissue, leveraging the significant difference in redox potential between the oxidizing extracellular environment and the reducing intracellular cytosol

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DSIP-CBBBP Fusion Peptide BBB Delivery Research (2024) The 2024 Frontiers in Pharmacology study by Shao and colleagues investigated a DSIP-CBBBP (cell-penetrating peptide) fusion construct expressed in Pichia pastoris in a PCPA-induced insomnia mouse model