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Although redressing the BA composition has proved to be beneficial in mouse models, it was unlikely to translate to human pathophysiology, as changes in BA composition in mice hardly reflect similar changes in BA profiles in humans due to the differences in BA composition 41

Always consult your healthcare provider before making any health decisions or changes to your treatment plan.

The most commonly reported adverse effects in Phase 2 trials were gastrointestinal in nature, including: Nausea (the most frequently reported) Vomiting Diarrhoea Constipation Decreased appetite These effects were generally dose-dependent and most pronounced during dose escalation, typically improving over time

Once-weekly dulaglutide with insulin therapy for type 2 diabetes: efficacy and safety results from a phase 4, randomized, placebo-controlled study

It limits the formation of new fat cells