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These shifts can slow the progression of obesity-driven diseases such as type 2 diabetes and heart disease, both of which spike after menopause
Most patients see meaningful regrowth after completing 3 cycles, approximately 3 months
As in the LEAN study, the primary outcome is histologic resolution of NASH without worsening of fibrosis after 72 weeks of treatment, while secondary outcomes include improvement in liver fibrosis (1 stage) with no worsening of NASH, NAFLD activity score, as well as multiple serum markers of fibrosis
Mollan SP, Ali F, Hassan-Smith G, Botfield H, Friedman DI, Sinclair AJ