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Rather than directly activating GABA-A receptors, the peptide appears to maintain homeostasis of the entire GABA receptor complex, preventing the desensitization and compensatory changes that produce tolerance and dependence
The Fire That Never Goes Out (Chronic Neuroinflammation) Microglia, the brain's immune cells, shift to a pro-inflammatory M1 phenotype to clear debris
Grant M
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These effects are typically most pronounced during dose escalation periods
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