The GLP-1 receptor is a type of cell surface receptor that binds to GLP-1, triggering a signaling cascade that leads to various effects, including the stimulation of insulin secretion, the inhibition of gastric emptying, and the promotion of satiety
Melanotan 1, is typically injected or administered as an implant, and binds to the melanocortin receptors 1, 3, 4, and 5 (MC1R, MC3R, MC4R, MC5R), with a strong effect on MC1R, leading to increased melanin production and tanning in test subjects [2, 3, 4, 5, 6]
Typically, patients start with a lower dosage to acclimate to the side effects, and during this initial period, significant weight loss should not be expected immediately
Most patients describe it less as appetite suppression and more as food taking up less mental space
Physical therapy helped temporarily but nothing stuck