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So, for example, during expression and purification of a recombinant protein, it may have a disulfide bond form, which wouldnt normally form in the proteins natural context

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Exosomal miR-4449 derived from DKD patient serum substantially accelerates tubular epithelial cell pyroptosis and oxidative stress through the transcriptional suppression of HIC1, leading to GSDMD-mediated pore formation and inflammatory cytokine secretion (167)

In that study, GSTu1 was suggested to be regulated by a novel noncoding RNA-mediated pathway [115]